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                             February 10, 2023

       Peter Wolfe
       Chief Financial Officer
       ZyVersa Therapeutics, Inc.
       2200 N. Commerce Parkway , Suite 208
       Weston , FL 33326

                                                        Re: ZyVersa
Therapeutics, Inc.
                                                            Registration
Statement on Form S-1
                                                            Filed January 27,
2023
                                                            File No. 333-269442

       Dear Peter Wolfe :

              We have limited our review of your registration statement to
those issues we have
       addressed in our comments. In some of our comments, we may ask you to
provide us with
       information so we may better understand your disclosure.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe our comments apply to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your
       response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to these comments, we may have additional comments.

       Registration Statement on Form S-1 filed January 27, 2023

       Cover Page

   1.                                                   Please revise your
heading on the cover page to also list the shares of common stock
                                                        issuable upon the
exercise of the warrants. In this regard, we note your statements
                                                        throughout the
prospectus that these underlying shares are also being registered pursuant
                                                        to the registration
statement.
   2.                                                   We note that your
placement agents will sell your common stock and accompanying
                                                        warrants on a "best
efforts" basis. Please revise the cover page to provide all information
                                                        required by Item
501(b)(8)(ii) and (iii) of Regulation S-K. Also, please tell us how the
                                                        following disclosure on
the cover page, and similar disclosure on page 149, is consistent
                                                        with a best-efforts
offering: "The delivery of the shares of Common Stock, the pre-funded
                                                        warrants and the
warrants to purchasers is expected to be made on or about [ ], 2023." In
 Peter Wolfe
FirstName LastNamePeter
ZyVersa Therapeutics, Inc.Wolfe
Comapany10,
February   NameZyVersa
            2023         Therapeutics, Inc.
February
Page  2 10, 2023 Page 2
FirstName LastName
         the event the offering will not remain open for an extended period of
time, please clarify.

3.       Please revise the cover page to clearly state that this is a best
efforts offering with no
         minimum and that your placement agents may not sell the entire amount
of common stock
         being offered.
4.       We note your disclosure on the cover page that your offering of common
shares and
         accompanying warrants will be at an "assumed" combined public offering
price. Please
         tell us whether you plan to amend prior to effectiveness to include
the final offering price
         as opposed to an assumed offering price. Also, please revise your
cover page to disclose
         that the combined public offering price per share and accompanying
warrant will be fixed
         for the duration of this offering.
5.       Please revise your cover page to highlight your intention to use
approximately $10.4
         million of the net proceeds from your offering to redeem all of the
PIPE Shares sold
         immediately prior to the closing of the Business Combination at 120%
of the issue price.
         Please also explain, if true, that only net proceeds received in
excess of this amount will
         be available for working capital and other general corporate purposes.
In making your
         revisions, state the difference between 1) the aggregate amount
received from the sale of
         the PIPE Shares immediately prior to the closing date of the Business
Combination, and 2)
         the aggregate repurchase price of the PIPE shares.
Use of Proceeds, page 57

6.       We note your intention to use approximately $10.4 million of the net
proceeds of the
         offering to redeem all of the PIPE Shares. However, we also note that
this is a best efforts
         offering with no minimum offering amount. Please revise your
disclosure to explain how
         proceeds will be allocated in the event you raise less than the full
$10.4 million required to
         redeem all PIPE Shares.
Management's Discussion and Analysis of Financial Condition and Results of
Operations
Liquidity and Capital Resources, page 119

7.       Please revise your liquidity and capital resources discussion to note
the following: 1) that
         approximately 99% of the then-outstanding shares of Larkspur Class A
common stock
         redeemed their shares in connection with the Business Combination; (2)
the unlikelihood
         that the company will receive significant proceeds from exercises of
the public warrants
         because of the disparity between the exercise price and the current
trading price of the
         Class A Common Stock; and (3) your intended use of $10.4 million of
the offering
         proceeds to redeem all of the PIPE shares . In addition, discuss the
effect of this offering
         on the company   s ability to raise additional capital.
 Peter Wolfe
ZyVersa Therapeutics, Inc.
February 10, 2023
Page 3
PIPE Transactions and Related Agreements
PIPE Registration Rights Agreement, page 153

8.    Your statement on page 153 that "this registration statement" was filed
to cover the resale
      of all the shares of common stock issuable upon conversion or exercise of
the PIPE Shares
      and the PIPE warrants is not consistent with the remainder of the
prospectus, which relates
      to a primary best efforts offering. Please reconcile.
General

9.    Where appropriate, revise the prospectus to discuss why you intend to
exercise your right
      to redeem the PIPE Shares and the associated risks such redemption may
pose to other
      shareholders given your liquidity and capital resources discussion. For
example, discuss
      how the redemption of the PIPE Shares would impact the cash you have
available for
      other purposes and to execute your business strategy, and how the
repurchase of the PIPE
      Shares could impact the market price of the company's common stock.
        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence of
action by the staff.

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.

       Please contact Lauren Hamill at 303-844-1008 or Laura Crotty at
202-551-7614 with any
other questions.



                                                           Sincerely,
FirstName LastNamePeter Wolfe
                                                           Division of
Corporation Finance
Comapany NameZyVersa Therapeutics, Inc.
                                                           Office of Life
Sciences
February 10, 2023 Page 3
cc:       Jared Kelly
FirstName LastName