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                              June 28, 2023

       Stephen C. Glover
       Chief Executive Officer
       ZyVersa Therapeutics, Inc.
       2200 N. Commerce Parkway, Suite 208
       Weston, FL 33326

                                                        Re: ZyVersa
Therapeutics, Inc.
                                                            Registration
Statement on Form S-1
                                                            Filed June 15, 2023
                                                            File No. 333-272657

       Dear Stephen C. Glover:

              We have limited our review of your registration statement to
those issues we have
       addressed in our comments. In some of our comments, we may ask you to
provide us with
       information so we may better understand your disclosure.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe our comments apply to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your
       response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to these comments, we may have additional comments.

       Registration Statement on Form S-1, filed June 15, 2023

       Cover Page

   1.                                                   Please revise your
cover page to disclose the date that the offering will end. Refer to Item
                                                        501(b)(8)(iii) of
Regulation S-K.
   2.                                                   We note your disclosure
that there is no minimum number of shares of securities or
                                                        minimum aggregate
amount of proceeds that is a condition for this offering to close and
                                                        that you may sell fewer
than all of the securities offered, which may significantly reduce
                                                        the amount of proceeds
received by you, and investors in this offering will not receive a
                                                        refund if you do not
sell all of the securities offered. We also note your disclosure that
                                                        because there is no
escrow account and no minimum number of securities or amount of
                                                        proceeds, investors
could be in a position where they have invested in you, but you have
                                                        not raised sufficient
proceeds in this offering to adequately fund the intended uses of the
 Stephen C. Glover
ZyVersa Therapeutics, Inc.
June 28, 2023
Page 2
         proceeds as described in the prospectus. Please revise your
registration statement to make
         similar disclosures in the Prospectus Summary and Use of Proceeds
sections.
3.       We note your disclosure on page 6 that you may use a portion of the
net proceeds of this
         offering to "redeem the remaining PIPE Shares pursuant to the Series A
Certificate of
         Designation." We also note your disclosure on page 50 that as a result
of the recently
         completed Best Efforts Offering, you redeemed "substantially all of
the PIPE Shares in
         accordance with the Series A Certificate of Designation." Please
revise your cover page
         to disclose that you may use a portion of the net proceeds of this
offering to redeem the
         remaining PIPE Shares pursuant to the Series A Certificate of
Designation, that the floor
         price of the PIPE Shares was reset to the applicable floor price of
$2.00 and that, to the
         extent the market price of your common stock is above the floor price,
the holders of such
         securities could be redeemed at a profit. Please also disclose here
and elsewhere, as
         appropriate, the number of PIPE Shares that are currently outstanding
that could be
         redeemed using the net proceeds of this offering.
Post Business Combination Related Party Transactions
Private Placement, page 136

4.       We note your disclosure that on June 5, 2023, you issued an aggregate
of 3,044,152 shares
         of common stock to certain members of the Sponsor in exchange for
increasing the
         duration of their lockup period with respect to all securities of the
company owned by
         such members. Please revise your disclosure to describe the material
terms of this
         transaction, including the length of the extended lockup period and
the total number of
         shares that the lockup period applies to. Additionally, to the extent
material, please
         disclose the reason for the extension of the lockup period and whether
the members of the
         Sponsor will have a lower cost basis in the shares of common stock
than investors in this
         offering.
Exhibits
FirstName LastNameStephen C. Glover
Comapany
5.         NameZyVersa
       Please file the form Therapeutics, Inc.form of pre-funded warrants, and
the agreement with
                            of warrants, the
       your
June 28,    placement
         2023  Page 2 agent for this offering as exhibits to your registration
statement.
FirstName LastName
 Stephen C. Glover
FirstName  LastNameStephen
ZyVersa Therapeutics, Inc. C. Glover
Comapany
June       NameZyVersa Therapeutics, Inc.
     28, 2023
June 28,
Page 3 2023 Page 3
FirstName LastName
        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence of
action by the staff.

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.

       Please contact Joshua Gorsky at 202-551-7836 or Laura Crotty at
202-551-7614 with any
questions.



                                                           Sincerely,

                                                           Division of
Corporation Finance
                                                           Office of Life
Sciences
cc:      John D. Hogoboom, Esq.